Name | Lactoferrin |
Synonyms | COLOSTRUM AIDS096157 Lactoferrin Lactoferricin B LACTOFERRIN, HUMAN LACTOFERRIN (BOVINE) LACTOFERRIN, HUMAN MILK LACTOTRANSFERRIN (BOVINE) LACTOSIDEROPHILIN (BOVINE) |
CAS | 146897-68-9 |
Molecular Formula | C141H224N46O29S3 |
Molar Mass | 3123.82 |
Density | 1.48±0.1 g/cm3(Predicted) |
Solubility | H2O: 1mg/mL |
Appearance | powder |
Color | pink |
PH | pH (20g/l, 25℃) : 5.2~7.2 |
Storage Condition | 2-8°C |
Physical and Chemical Properties | Bioactive Lactoferrin 17-41 (Lactoferricin B) corresponds to residue 17-41 of bovine lactoferrin and has antibacterial activity against various microorganisms such as gram-positive and gram-negative bacteria, viruses, protozoa and fungi. Lactoferrin 17-41 has anti-tumor activity. |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
WGK Germany | 3 |
density | 1.48±0.1 g/cm3(Predicted) |
storage conditions | 2-8°C |
solubility | H2O: 1 mg/mL |
morphology | powder |
color | pink |
PH value | pH (20g/l, 25℃) : 5.2~7.2 |
Lactoferrin 17-41 (Lactoferricin B) has an MIC of 30 μg/ml against E. coli ATCC 25922.
Lactoferrin 17-41 significantly stimulates apoptosis of HT-29 cells and displays cytotoxic activity on HT-29 cells.
Lactoferrin 17-41 variously regulats transcription of genes involved in the p53 signaling pathway, such as PMAIP-1, TP5313, and SFN.
Lactoferrin 17-41 can bind LPS from Gram-negative bacteria and that it can inhibit LPS induced cytokine response in human monocytic cells.
Cell Viability Assay
Cell Line: | HT-29 cells |
Concentration: | 50, 100, 200, 400, 800 or 1000 µg/mL |
Incubation Time: | 4, 12, 24 or 48 hours |
Result: | More effective at inducing apoptosis at 400 µg/mL. Higher toxicity is shown at 800 µg/mL. |
dangerous goods mark | B |
safety instructions | 22-24/25 |
WGK Germany | 3 |
biological activity | Lactoferrin 17-41 (Lactoferricin B) corresponds to residue 17-41 of bovine lactoferrin and has antibacterial activity against various microorganisms such as gram-positive and gram-negative bacteria, viruses, protozoa and fungi. Lactoferrin 17-41 has anti-tumor activity. |
Cell Line: | HT-29 cells |
Concentration: | 50, 100, 200, 400, 800 or 1000 µg/mL |
Incubation Time: | 4, 12, 24 or 48 hours |
Result: | More effective at inducing apoptosis at 400 µg/mL. Higher toxicity is shown at 800 µg/mL. |